Search Result

Results for "

chemotherapeutic agents

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Akt (2) Antibiotic (3) Antifolate (3) Apoptosis (12) Aurora Kinase (1) Autophagy (6) Bacterial (4) Caspase (1) Dihydrofolate reductase (DHFR) (2) DNA Alkylator/Crosslinker (9) DNA/RNA Synthesis (2) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) EGFR (3) Endogenous Metabolite (3) GSK-3 (1) Influenza Virus (1) Isotope-Labeled Compounds (4) MMP (1) NF-κB (1) Nucleoside Antimetabolite/Analog (2) Parasite (2) PKC (2) Topoisomerase (2)
By Research Areas:	Cancer (35) Infection (7) Inflammation/Immunology (10) Metabolic Disease (1)

By Targets:

ADC Cytotoxin (2)

Akt (2)

Antibiotic (3)

Antifolate (3)

Apoptosis (12)

Aurora Kinase (1)

Autophagy (6)

Bacterial (4)

Caspase (1)

Dihydrofolate reductase (DHFR) (2)

DNA Alkylator/Crosslinker (9)

DNA/RNA Synthesis (2)

Drug Metabolite (3)

Drug-Linker Conjugates for ADC (1)

EGFR (3)

Endogenous Metabolite (3)

GSK-3 (1)

Influenza Virus (1)

Isotope-Labeled Compounds (4)

MMP (1)

NF-κB (1)

Nucleoside Antimetabolite/Analog (2)

Parasite (2)

PKC (2)

Topoisomerase (2)

By Research Areas:

Cancer (35)

Infection (7)

Inflammation/Immunology (10)

Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108391

C8-Ceramide N-Octanoyl-D-erythro-sphingosine	Apoptosis PKC Autophagy	Inflammation/Immunology Cancer
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro .

HY-17419

Ifosfamide

5 Publications Verification

DNA Alkylator/Crosslinker Cancer

Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
HY-13585

Carmustine

5+ Cited Publications

DNA Alkylator/Crosslinker Cancer

Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

Ifosfamide 5 Publications Verification	DNA Alkylator/Crosslinker	Cancer
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

Carmustine 5+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating* agent* with antitumor activity .

HY-115932

Aurora kinase-IN-1	Aurora Kinase Apoptosis	Cancer
Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents .

HY-13761

Teniposide

5+ Cited Publications

VM26
Topoisomerase Cancer

Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.
HY-13747

Semustine

1 Publications Verification

DNA Alkylator/Crosslinker Cancer

Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent .
HY-B1782

Sulfamoxole

Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .

Teniposide 5+ Cited Publications VM26	Topoisomerase	Cancer
Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.

Semustine 1 Publications Verification	DNA Alkylator/Crosslinker	Cancer
Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent .

Sulfamoxole
Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial *agent*. Sulfamoxole can be used for the study of pediatric infections .

HY-19543

Brusatol 20+ Cited Publications NSC 172924
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-108315

6-Aminochrysene 6-Chrysenamine	Others	Inflammation/Immunology Cancer
6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer.

HY-B0147A

Pefloxacin mesylate 2 Publications Verification Pefloxacinium mesylate	Bacterial Antibiotic	Infection
Pefloxacin mesylate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

HY-B0147

Pefloxacin 2 Publications Verification Pefloxacinium	Bacterial Antibiotic	Infection
Pefloxacin is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

HY-108251S

Methotrexate metabolite-d3 DAMPA-d₃	Isotope-Labeled Compounds Antifolate Drug Metabolite	Inflammation/Immunology
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].

HY-17419S1

Ifosfamide-d4	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

HY-13585S

Carmustine-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

HY-119172

NSC-60339	Bacterial	Infection Inflammation/Immunology Cancer
NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent .

HY-13585R

Carmustine (Standard)	DNA Alkylator/Crosslinker	Cancer
Carmustine (Standard) is the analytical standard of Carmustine. This product is intended for research and analytical applications. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-B0147B

Pefloxacin mesylate dihydrate Pefloxacinium mesylate dihydrate	Bacterial Antibiotic	Infection
Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

HY-B0245

Busulfan 5+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Others	Cancer
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .

HY-14596

Genistein Maximum Cited Publications 39 Publications Verification NPI 031L	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-W048496

2'-O-(2-Methoxyethyl)-cytidine	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-cytidine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-W048495

2'-O-(2-Methoxyethyl)-uridine	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-108251R

Methotrexate metabolite (Standard) DAMPA (Standard)	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-B1946

Dimethoate
Dimethoate is an effective systemic insecticide for use on plants, has shown promise as a chemotherapeutic agent for control of cattle grubs and certain other insect pests of farm animals, and has high contact toxicity to house-flies and many other insects .

HY-19542

C6 Ceramide 1 Publications Verification C6-Cer; N-Hexanoylsphingosine
C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-14596S

Genistein-d4 NPI 031L-d₄	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein-d₄ is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis[1][2].

HY-14596R

Genistein (Standard) Maximum Cited Publications 39 Publications Verification NPI 031L (Standard)	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-B1946S

Dimethoate-d6	Isotope-Labeled Compounds	Others
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an effective systemic insecticide for use on plants, has shown promise as a chemotherapeutic agent for control of cattle grubs and certain other insect pests of farm animals, and has high contact toxicity to house-flies and many other insects[1].

HY-19824

3PO 15+ Cited Publications	Autophagy	Cancer
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC₅₀s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD ⁺ and NADH. 3PO can be used for the research of cancer .

HY-N3446

IVHD-valtrate	Apoptosis	Cancer
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

HY-120574

TH1338	ADC Cytotoxin Topoisomerase	Cancer
TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile .

HY-147271

Mal-PEG8-Val-Ala-PAB-Exatecan	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research .

HY-161098

Apoptosis inducer 14	Apoptosis	Cancer
Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC₅₀ values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively .

HY-16965

TH287 2 Publications Verification	DNA/RNA Synthesis	Cancer
TH287 is a potent and selective inhibitor of MTH1, with an IC₅₀ of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research .

HY-16965A

TH287 hydrochloride	DNA/RNA Synthesis	Cancer
TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC₅₀ of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research .

HY-150650

S07-2001	Others	Cancer
S07-2001 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 2.08 μM. S07-2001 enhances the activity of Doxorubicin against cancer cells. S07-2001 has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-108251

Methotrexate metabolite 1 Publications Verification DAMPA	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent . Methotrexate metabolite is an antimalarial agent, which inhibits the parasite growth with an IC₅₀ of 446 nM against the antifolate-sensitive strain and 812 nM against the highly resistant strain under physiological folate conditions. Methotrexate metabolite is inactive against mammalian cells. Methotrexate metabolite is a minimal inhibitor of dihydrofolate reductase among metabolites of methotrexate .

HY-150649

S07-2005 (racemic)	Others	Cancer
S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-12455

Duocarmycin A	ADC Cytotoxin Apoptosis Caspase	Cancer
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels .

HY-B1080A

Tilorone 1 Publications Verification	Influenza Virus Akt	Infection Metabolic Disease Inflammation/Immunology Cancer
Tilorone is an orally active antiviral agent and interferon inducer that also has potential antineoplastic, immunomodulatory, and metabolic modulating effects. Tilorone induces an abnormally delayed interferon response and primarily stimulates interferon production in lymphoid tissue. Thus, Tilorone exerts antiviral effects and can be used as a chemotherapeutic agent. Tilorone has the potential to inhibit type 2 diabetes by increasing glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels .

HY-113914

9-ING-41 1 Publications Verification Elraglusib	GSK-3 Apoptosis Autophagy	Cancer
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC₅₀ of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents .

HY-119312

C8 Dihydroceramide	PKC	Cancer
C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro .

HY-150644

S07-2010	Others	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Inflammation/Immunology Cancer
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

Cat. No.	Product Name	Category	Target	Chemical Structure